101 things you (maybe) didn’t know about MacVector: #14 – How To Align Non-Overlapping Protein Fragments Against A Parent Protein

The classic algorithm for aligning multiple protein sequences is ClustalW. Normally, it does a great job of aligning related DNA and Protein sequences and can handle thousands of sequences if required. However, one place where it struggles is if you are aligning non-overlapping segments of DNA or Protein against a parental full-length sequence. The reason […]

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Clustering an alignment

Sometimes it is useful to sort, or cluster, an alignment according to the similarity/identity of its sequences. With such a sorted alignment you are able to more easily visualise closely related sequences as they will be together in an alignment with more distantly related sequences being much further apart. If you want to quickly cluster […]

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Alignments in MacVector

Update 19 August 2013: We’ve added support for Muscle and T-Coffee to the MSA editor We get a lot of comments and questions from users on the various alignment functions in MacVector. They say there’s more than one way to skin a cat (not that I’ve done that – I have skinned a catfish, but […]

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