It’s very quick to download the latest version of a sequence if you know its accession number. When you start working with a new sequence, it’s the best place to start.
If you do not know the accession number, then it’s still easy, but you might need to perform a more complex search to only retrieve a few hits. For example “ORGANISM=Homo sapiens, GENE=“Presenilin”
If you just want to “refresh” your own copy of a sequence with the latest published annotation, then use Import Features instead.
Remember that due to changes at the NCBI, BLAST and Entrez will only work in MacVector 15.1 and later.