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  • How to change the circular origin of a sequence

    While most MacVector analysis algorithms can handle circular sequences, its sometimes useful to be able to set the “12 o’clock” point to a different location on the circle. This is easy to do with recent MacVector releases. If you are using MacVector 13.5, then all you have to do is position the flashing caret between…

    Read more: How to change the circular origin of a sequence
    Feb 22, 2016

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    by

    Chris
    in Tips

  • Test PCR Primer Pairs using the Primer Design (Primer3) Interface

    Over the past few releases of MacVector, we have been adding a lot of functionality to the Quicktest Primer and Primer Design/Test Pairs interfaces and slowly removing the old outdated primer design functions. The general strategy is that anything you need to do with a single primer, you can accomplish using the Quicktest Primer interface.…

    Read more: Test PCR Primer Pairs using the Primer Design (Primer3) Interface
    Feb 22, 2016

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    by

    Chris
    in Tips

  • How to find and open all the sequences on your computer containing a specific gene.

    How often have you had a vector or sequence open and thought “I’m sure I have other vectors with that gene, but I can’t remember where they are”? If you are using MacVector 13.5, its very easy to quickly search folders on your hard drive to find all the sequences that contain that gene, then…

    Read more: How to find and open all the sequences on your computer containing a specific gene.
    Feb 19, 2016

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    by

    Chris
    in Tips

  • How to identify methylation blocked Restriction Sites

    MacVector currently does not have a built-in function for recognizing restriction sites that are blocked by the DAM or DCM methylases. However, there is a simple workaround that lets you visually identify those sites in the restriction enzyme analysis result windows. The basic idea is that you create additional restriction enzyme sites for each enzyme…

    Read more: How to identify methylation blocked Restriction Sites
    Feb 19, 2016

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    by

    Chris
    in Tips

  • Downloading BLAST Hits from the NCBI

    When you use MacVector to run a BLAST search, did you know that you can download any matching sequences directly from the BLAST Description List window? Simply select text on any part of the line(s) representing the sequence you want to download and choose Database | Retrieve To Desktop or Database | Retrieve To Disk…

    Read more: Downloading BLAST Hits from the NCBI
    Feb 18, 2016

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    by

    Chris
    in Tips

  • Creating cloning construction flowcharts in third party applications

    We’ve previously discussed how every ligation is documented. You get a “Frag” annotation that contains the date, source sequence, enzymes used and any end modification that was done to that fragment during the ligation. However, we had regular requests to make it easier for user to document their constructs in other ways. For example being…

    Read more: Creating cloning construction flowcharts in third party applications
    Jan 28, 2016

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    by

    Chris
    in Tips

  • Clearing the “find” history in the Primer and Find dialogs.

    Many tools in MacVector store a history of sequences, or search terms, that you have previously used. For example the Find dialog and Primer Design tools. This is accessed using a drop down menu to the right of the box where you would normally type, or paste, your sequence. This is to allow easy access…

    Read more: Clearing the “find” history in the Primer and Find dialogs.
    Jan 21, 2016

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    by

    Chris
    in Tips

  • Simulated Agarose Gels

    MacVector 14.5 has a Agarose Gel interface which allows you to view photo-realistic recreations of restriction digests of linear and circular DNA molecules. The gels look so realistic that users have had a hard time telling photos of their own digests from the simulation in MacVector. When you first use the new tool and compare…

    Read more: Simulated Agarose Gels
    Jan 18, 2016

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    by

    Chris
    in Releases, Techniques, Tips

  • MacVector 14.5 is out!

    We are pleased to announce that MacVector 14.5 was released at the end of 2015. To upgrade to this version if you are running OS X 10.7 or later then just go to MACVECTOR > CHECK FOR UPDATES… to allow MacVector to automatically upgrade. If you are running OS X 10.6 then you will need…

    Read more: MacVector 14.5 is out!
    Jan 4, 2016

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    by

    Chris
    in Releases

  • Happy holidays from all of us at MacVector!

    Read more: Happy holidays from all of us at MacVector!
    Dec 24, 2015

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    by

    Chris
    in General
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