Sequence Analysis Tools for Molecular Biologists

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Database Searching

NCBI Entrez

The National Center for Biotechnology Information (NCBI) maintains a number of sequence databases that can be accessed over the Internet. MacVector has a built-in Internet database browser that lets you search the NCBI's Entrez databases for sequences using combinations of search terms such as author, organism, keywords, accession number etc.


You can combine search terms

Sequences that match the search terms can be downloaded either individually or in batches to your desktop or to a folder on your hard drive. Sequences are retrieved with all of their associated annotations and features intact. These can be viewed and edited in MacVector, or used for additional analyses.


The Basic Local Alignment Search Tool (BLAST) algorithm is a popular program for identifying sequences in a databases that share sequence similarity to a search sequence. MacVector provides an integrated Internet BLAST interface to the databases at the NCBI. You can search using any of the blastn, blastp, tblastn, blastx and tblastx algorithms using any sequence databases available at the NCBI. The BLAST searches take place in the background, so you can continue to work with MacVector while one or more searches are in progress. As well as providing a standard BLAST report of the best aligning sequences in the database, MacVector also lets you select sequence in the "hitlist" and directly download those to your desktop or hard drive for further analysis.


MacVector lets you customize the


Simply highlight the sequences you

Align To Folder

As well as providing database

As well as displaying a


The Align to Folder text


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Comparison of MacVector Editions

MacVector Cloning Edition

What has changed since my version?

What's New in MacVector?

Graphical Sequence Editing

Agarose Gel Simulation

Gateway and TOPO Cloning

Gibson/LIC Assembly


Primer Design

DNA Analysis

Protein Analysis

Database Searching

Multiple Sequence Alignment

Sequence Confirmation

cDNA Alignment

macOS Mojave Dark Mode

System Requirements