Sequence Analysis Tools for Molecular Biologists

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Mojave Dark Mode

macOS Mojave (macOS 10.14) has a new "Dark Mode" appearance option, where the interface changes to have dark window backgrounds with light colored text. The advantages of dark mode include improved readability of text, better contrast and reduced eye strain. Users who like to work at night or in darker environments may also benefit from Dark Mode.

Applications built for macOS do not automatically support Dark Mode, but have to be specifically coded to take advantage of the feature. MacVector 17 was the first release of MacVector to specifically support Dark Mode.


All of the major window types and tabs in MacVector have been recoded to support dark backgrounds and light text;




Adjusting Default Colors

MacVector's default colors have been designed with the Aqua ("Light") mode in mind. So the colors may not always be ideal for your needs, especially in Dark Mode. But, MacVector gives you a lot of control over the default appearance of the display.

Here the MacVector | Preferences -> Color pane gives you control over many of the text colors and the chromatogram trace colors;


To change the default appearance of the graphical Map features, click on the Change Default Symbol Appearance button in the MacVector | Preferences -> Map View pane;


This opens the Default Symbol Editor where you can modify many aspects of the appearance of every GenBank feature type. From a Dark Mode perspective, the label color might be one of the more important settings. Note that you can actually select multiple (or all) feature types in the left hand pane and change specific settings for all of the feature types with a single click.


Forcing MacVector to Open in Light Mode

If you would rather have MacVector run with white window backgrounds, even when you are running macOS in Dark Mode, this can be accomplished with some simple commands. To do this, you should open the macOS application You will find this in the /Applications/Utilities/ folder.

To force MacVector to always open in "Light Mode", close MacVector, then type or copy/paste the following command into the Terminal window;

defaults write com.macvector.MacVector NSRequiresAquaSystemAppearance -bool YES

When you start MacVector again, it should be running in Light Mode.

If you want to reset that preference, open Terminal and type/paste this command;

defaults delete com.macvector.MacVector NSRequiresAquaSystemAppearance


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Comparison of MacVector Editions

MacVector Cloning Edition

What has changed since my version?

What's New in MacVector?

Graphical Sequence Editing

Agarose Gel Simulation

Gateway and TOPO Cloning

Gibson/LIC Assembly


Primer Design

DNA Analysis

Protein Analysis

Database Searching

Multiple Sequence Alignment

Sequence Confirmation

cDNA Alignment

macOS Mojave Dark Mode

System Requirements