General musings from the MacVector team about sequence analysis, molecular biology, the Mac in general and of course your favorite sequence analysis app for the Mac!

Press releases

July 2015
MacVector announces MacVector Cloning Edition.

FOR IMMEDIATE RELEASE

MacVector, Inc. has just released MacVector Cloning Edition, a lower cost package aimed solely at users who just need to design and document clone construction. MacVector Cloning Edition provides these users with a highly affordable package.

The product, previously known as “MacVector”, has been rebranded as MacVector Pro. While MacVector Pro has a huge amount of functionality, user feedback has indicated that many do not require access to all the features available and are quite happy with basic sequence manipulation and documentation functions. MacVector Cloning Edition allows you to design primers, store them in the primer database, scan sequences against the primer database, digest, store and ligate multiple DNA fragments into cloning vectors with full documentation of each ligated fragment. The graphical maps have the same highly customizable feature rich annotated sequences with a sequence overview as MacVector Pro and it will also export publication quality maps.

A license of MacVector Cloning Edition is perpetual rather than requiring an annual subscription. It also comes with a full year of free updates. Purchasers of MacVector Cloning Edition are eligible to a cost only upgrade to MacVector Pro at any time with no penalty for starting out with MacVector Cloning Edition.

With the availability of the MacVector Cloning Edition, there is now a MacVector product to meet all molecular biologists needs: MacVector Free, MacVector Cloning Edition, MacVector Pro and MacVector Pro with Assembler.

MacVector, Inc’s CEO, Dr. Kevin Kendall, said “Many users say they “don’t need all of the bells and whistles” of MacVector Pro and we have been asked many times if we have an application for limited use, as some users find it hard to justify the cost in their budget or grant application. As usual we’ve listened to these users. MacVector Cloning Edition contains all the user needs for digestion, ligation, restriction mapping, downloading sequences from Entrez with the usual easy to use interface. Yet the price is considerably less.”

MacVector Cloning Edition is fully supported on any 64 bit Mac running OS X 10.6 Snow Leopard to Mac OS X 10.10 Yosemite.

MacVector, Inc. was formed at the beginning of 2007 to develop, support and sell MacVector and Assembler.  MacVector has offices in the US and the UK, along with distributors in Japan, Taiwan, Israel and Australia. 

MacVector is a desktop sequence analysis application running on the Macintosh. 

Assembler is a desktop sequence assembly add on for MacVector.

http://www.macvector.com/MacVector/macvectorcloningedition.html

Comparison of the various versions:

http://www.macvector.com/MacVector/macvectoreditions.html

July 2015

MacVector, Inc. announces the first 64 bit version of MacVector, version 14.

FOR IMMEDIATE RELEASE

MacVector, Inc. has just released MacVector 14.

MacVector 14 is a fully 64 bit application using only modern Apple frameworks. This enhances performance with large sequences and increases compatibility for future releases of OS X.

New tools include the primer database tool. Users are able to save primers from the two primer design and testing tools directly to a central primer database and to scan sequences against that database. The primer database is backwards compatible with user’s own subsequence files. For sequence assembly, Bowtie has been updated to version 2 so that reference assemblies can incorporate insertions and deletions. INDELs are graphically represented on the reference contig.
MacVector, Inc’s CEO, Dr. Kevin Kendall, said “With MacVector 14 our hardworking developers have finished rewriting MacVector to use only modern OS X libraries and at the same time made it a fully 64 bit application. That might not mean much to the average user, but let’s just say as long as you have a modern Mac with plenty of memory, MacVector 14 is fast with large sequences. Furthermore, now that we are a fully 64 bit application expect to see many performance enhancements in the releases following MacVector 14.”
MacVector 14 is fully supported on any 64 bit Mac running OS X 10.6 Snow Leopard to Mac OS X 10.10 Yosemite.
MacVector, Inc. was formed at the beginning of 2007 to develop, support and sell MacVector and Assembler.  MacVector has offices in the US and the UK, along with distributors in Japan, Taiwan, Israel and Australia. 

MacVector is a desktop sequence analysis application running on the Macintosh. 

Assembler is a desktop sequence assembly add on for MacVector.

http://www.macvector.com

Evaluation version

http://www.macvector.com/try.html

What’s New in MacVector 14:

http://www.macvector.com/MacVector/what’snewinmacvector14.0.html

November 2014

MacVector, Inc. Announces the Release of MacVector 13.5

FOR IMMEDIATE RELEASE

MacVector 13.5 makes comparing large sequences faster and improves handling of NGS data. Additionally the new interface, introduced in MacVector 13.0, has had many improvements in response to user feedback. 

Improvements include enhancements to Align To Reference, which now handles circular sequences, and Align to Folder, which will scan large NGS datasets with a DNA or protein query. Both tools also allow you to extract matching reads into FASTQ files for further analysis or assembly. Assembler will compare the expression level of genes across different reference assemblies and the optimized Dot Plot tool now allows comparisons of bacterial genomes in just a few seconds.

MacVector, Inc’s CEO, Dr. Kevin Kendall, said “With MacVector 13.5 we’ve addressed many of the problems facing users who are confronted with large sets of NGS sequencing reads, but are really just interested in a few genes. You are able to scan a related protein sequence against such a dataset to pick out reads for just that sequence, simplifying subsequent assembly. Furthermore a continued approach to performance tuning has ensured this release of MacVector is faster than ever.”

MacVector 13.5 is fully supported on OS X 10.6 Snow Leopard to Mac OS X 10.10 Yosemite.

MacVector, Inc. was formed at the beginning of 2007 to develop, support and sell MacVector and Assembler.  MacVector has offices in the US and the UK, along with distributors in Japan, Taiwan and Australia. 

MacVector is a desktop sequence analysis application running on the Macintosh. 

Assembler is a desktop sequence assembly add on for MacVector.

http://www.macvector.com

Evaluation version

http://www.macvector.com/try.html

What’s New in MacVector 13.5:

http://macvector.com/MacVector/what’snewinmacvector13.5.html

April 2014

“MacVector, Inc. Announces the Release of MacVector 13

FOR IMMEDIATE RELEASE

MacVector, Inc. has just released MacVector 13; a major update with both new functionality and a new look.

MacVector 13 has a muted interface to suit the look and feel of Mavericks and many windows and dialogs have been redesigned. The results windows are now tabbed to improve data visualization and reduce window clutter. A good proportion of the application has also been rewritten to suit current and future releases of OS X.

Velvet has been added to the Assembler sequence assembly plugin. Velvet is designed for de novo assembly of data from short read sequencers. Along with the existing plugins, Phrap for older (Sanger) sequencing data and Bowtie for reference assembly, this gives the user great flexibility for assembling sequencing data in a single application.

The latest revision of the QuickTest Primer tool aids the introduction of new restriction sites around the primary binding site of the primer as well as displaying existing ones. It has visual representation of translationally silent and non silent mutations in those sites. A new tab in the Chromatogram sequence window displays the quality values and areas under each trace curve for each sequence residue in an exportable tab delimited format. MacVector 13 also has enhanced Applescript support for batch processing of sequences.

MacVector, Inc’s President, Dr. Kevin Kendall, said “You deserve the best sequence analysis application and MacVector 13 will not disappoint! MacVector 13 has both new tools and a redesign. QuickTest Primer now makes it easy to introduce a new restriction site into your primer without affecting coding. It shows you any potential translationally silent new sites and with a mouse click you can add that new restriction site to your primer.”

MacVector 13 is fully supported on Mac OS X 10.9 Mavericks to OS X 10.6 Snow Leopard.

MacVector, Inc. was formed at the beginning of 2007 to develop, support and sell MacVector and Assembler. MacVector has offices in the US and the UK, along with distributors in Japan, Taiwan and Australia.

MacVector is a desktop sequence analysis application running on the Macintosh.
Assembler is a desktop sequence assembly add on for MacVector.

http://www.macvector.com

Evaluation version

http://www.macvector.com/try.html

What’s New in MacVector 13:

http://macvector.com/MacVector/what’snewinmacvector13.0.html

December, 2012
MacVector, Inc. Announces the Release of MacVector Free.

FOR IMMEDIATE RELEASE

MacVector, Inc. has just released MacVector Free; a free basic edition of the popular sequence analysis application for Macintosh computers.

The recently released MacVector 12.7 sees the introduction of a new complimentary basic edition, MacVector Free. MacVector Free includes many of the basic sequence editing, documentation and analysis functions that molecular biologists use on a day to day basis.

With MacVector Free, users can open or download sequences in most sequence formats, edit them, print, copy sequences, modify text and graphics for publication ready figures, and save in any supported format. It will perform simple click cloning operations (although not via the new Cloning Clipboard) to generate new constructs. Entrez and BLAST are available along with the Find functionality. MacVector Free lets users share MacVector files and data with more casual users or collaborators without having to convert sequences into a common format, often losing information in the process.

MacVector Free comes with a perpetual license that can be easily upgraded to enable the more powerful analysis tools which are available in the other editions.

MacVector Free is fully supported on Mac OS X 10.8 Mountain Lion to to OS X 10.5 Leopard.

MacVector, Inc’s President, Dr. Kevin Kendall, said “We’re very happy to be able to provide MacVector Free so that even casual users can take advantage of MacVector’s powerful sequence viewing and file format conversion capabilities. MacVector Free should be an essential software tool for any Macintosh-owning molecular biologist.”

MacVector, Inc. was formed at the beginning of 2007 to develop, support and sell MacVector and Assembler. MacVector has offices in the US and the UK, along with distributors in Japan, Taiwan and Australia.

MacVector is a desktop sequence analysis application running on the Macintosh.

Assembler is a desktop sequence assembly add on for MacVector.

http://www.macvector.com

Evaluation version

http://www.macvector.com/trymacvector.html

MacVector Free

http://www.macvector.com/MacVector/macvectorfree.html

What’s New in MacVector 12.7:

http://www.macvector.com/MacVector/what’snewinmacvector12.7.html

November, 2012
MacVector, Inc. Announces the Release of MacVector 12.7

FOR IMMEDIATE RELEASE

MacVector, Inc. has just released MacVector 12.7; a major update aimed at helping all molecular biologists with their cloning experiments.

The new Cloning Clipboard tool simplifies the creation of new DNA constructs. The new functionality lets you join molecules together using an intuitive drag and drop interface and also lets you easily accomplish cloning constructs that were difficult with earlier versions of MacVector. This tool will design and document all subcloning operations from simple digests to complex multi fragment procedures such as Multisite Gateway. The history of every ligation event is annotated to the sequence showing the enzymes used, the date and any end modifications.

There’s also been performance enhancements to the Dot Plot tool and to the Align To Reference editor, allowing you to now run pairwise alignments of whole genomes in just a few minutes or to align hundreds of thousands of NGS Reads against a reference genome. New options in the Reverse Translation tool allowing you to optimize codon usage when reverse translating a protein.

MacVector 12.7 also sees the introduction of a new free basic edition, Macvector Free. You can use MacVector Free to open or download sequences in any supported format, edit them, print, copy sequences, text and graphics, and save in any supported format. You can even create new sequence constructs by clicking on restriction enzyme sites, copying and pasting into other sequence molecules.

MacVector, Inc’s President, Dr. Kevin Kendall, said “Most molecular biologists have to clone and subclone their genes of interest. The new Cloning Clipboard in MacVector simplifies this task dramatically and allows the documentation of multi-fragment constructs in an intuitive way. Every ligation is documented with the overhang ends and the date and enzymes used. MacVector is designed by molecular biologists, not sales people. We’re also very happy to be able to provide MacVector Free so that even casual users can take advantage of MacVector’s powerful sequence viewing capabilities ”

MacVector 12.7 is fully supported on Mac OS X 10.8 Mountain Lion to to OS X 10.5 Leopard.

MacVector, Inc. was formed at the beginning of 2007 to develop, support and sell MacVector and Assembler. MacVector has offices in the US and the UK, along with distributors in Japan, Taiwan and Australia.

MacVector is a desktop sequence analysis application running on the Macintosh.
Assembler is a desktop sequence assembly add on for MacVector.

http://www.macvector.com

Evaluation version

http://www.macvector.com/trymacvector.html

What’s New in MacVector 12.7:

http://www.macvector.com/MacVector/what’snewinmacvector12.7.html

June 2012
MacVector, Inc. Announces the Release of MacVector 12.6

FOR IMMEDIATE RELEASE

MacVector, Inc. has just released MacVector 12.6; a major update with many new and enhanced features that further simplifies DNA and protein sequence analysis for all molecular biologists.

MacVector 12.6 has a brand new interactive tool for designing primers, QuickTest Primer, which redefines the ease and flexibility with which you can design primers. You can view secondary structure in real time as you enter a primer sequence and add restriction sites or mismatches for site directed mutagenesis whilst viewing the modified translated sequence.

MacVector 12.6 also supports importing annotation from genome browsers with support of GFF, GFF3, and BED files to annotate blank sequences.

The reference assembly additions to Assembler has continued to be improved with major performance enhancements for displaying large assemblies and the ability to import existing BAM/SAM and ACE alignments for display. Visualization of reference assemblies has been improved with interactivity between contigs and reference contigs as well as SNPs being annotated to the contigs as well as being shown in the SNP report.

MacVector 12.6 is fully supported on Mac OS X 10.7 (Lion), Leopard and Snow Leopard.

MacVector, Inc’s President, Dr. Kevin Kendall, said “QuickTest Primer completely changes the way primers can be designed on a computer. It simplifies primer design by showing your primer and its statistics in realtime. Does your primer have a hairpin? Nudge it along your template until the hairpin goes. Want to add a restriction site? Then add one and again nudge your primer to optimise the oligo. Want to see how a CDS translation is affected by your modified primer? View both the original and modified amino acid sequence.”

MacVector, Inc. was formed at the beginning of 2007 to develop, support and sell MacVector and Assembler. MacVector has offices in the US and the UK, along with distributors in Japan, Taiwan and Australia.

MacVector is a desktop sequence analysis application running on the Macintosh.
Assembler is a desktop sequence assembly add on for MacVector.

http://www.macvector.com

Evaluation version

http://www.macvector.com/trymacvector.html

What’s New in MacVector 12.6:

http://www.macvector.com/MacVector/what’snewinmacvector12.6.html

December 2011
MacVector, Inc. Announces the Release of MacVector 12.5

FOR IMMEDIATE RELEASE

MacVector, Inc has just released MacVector 12.5; a major update with many new and enhanced features that further simplifies DNA and protein sequence analysis for all molecular biologists. This release is aimed at improving sequence alignments and adding further support for NGS assembly.

In MacVector 12.5 Muscle and T-coffee have been added to the Multiple Sequence Alignment editor, complementing the existing ClustalW algorithm. Performance has been increased in many areas as well as many tools been redesigned for easier usage.

Assembler will now support Bowtie assemblies of FastQ data with variant calling of reference alignments in Assembler has been added with SNP Reporting in the Align to Reference SNP tab enhanced to report differences between the consensus and reference sequences, including any amino acid changes that the change would have on any CDS feature belonging to the reference.

MacVector 12.5 is fully supported on Mac OS X 10.7 (Lion), Leopard and Snow Leopard.

MacVector, Inc’s President, Dr. Kevin Kendall, said “With this release we’ve concentrated on improving performance and giving users more options to align their sequences. We’ve very pleased to bring Muscle and T-Coffee especially since these are often requested by users. We’ve increased the performance of existing alignment options. ..and of course with the addition of Bowtie, we’re giving the user an easy way to make sense of their next generation sequence data. With this tool you can create genome sized assemblies on even quite modestly powered Macs. ”

MacVector, Inc. was formed at the beginning of 2007 to develop, support and sell MacVector and Assembler. MacVector has offices in the US and the UK, along with distributors in Japan, Taiwan and Australia.

MacVector is a desktop sequence analysis application running on the Macintosh.
Assembler is a desktop sequence assembly add on for MacVector.

http://www.macvector.com

Evaluation version

http://www.macvector.com/trymacvector.html

What’s New in MacVector 12.5:

http://macvector.com/blog/2011/10/macvector-12-5-new-features/

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